Current research

 

Finding genes that predispose to multiple sclerosis
Study ID: 2006/02

Field: Not available

Country: Australia

Recruitment: Closed

Publications:

Tissue Antigens. 2009 Jul;74(1):17-21. Epub 2009 Apr 21 J Neuroimmunol. 2009 Jun 25;211(1-2):105-9. Epub 2009 Apr 17

Hum Mol Genet. 2013 Feb 12. PMID:23406874

Binder, M.D., Fox, A.D., Merlo, D., Johnson, L.J., Giuffrida, L., Calvert, S.E., Akkermann, R., Ma, G.Z.M., ANZgene, Perera, A.A., Gresle, M.M., Laverick, L., Foo, G. Fabis-Pedrini, M.J., Spelman, T., Jordan, M.A., Baxter, A.G., Foote, S., Butskueven, H., Kilpatrick, T.J., Field, J. (2016). “Common and low frequency variants in MERTK are independently associated with Multiple Sclerosis susceptibility with discordant association dependent upon HLA-DRB1*15:01 status” PLoS Genetics. 12(3):e1005853

Gu B.J., Field J., Dutertre S., Ou A., Kilpatrick T.J., Lechner-Scott J., Scott R., Lea R., Taylor B.V., Stankovich J., Butzkueven H., GresleM., Laws S.M., Petrou S., Hoffjan S., Akkad D.A., Graham C.A., Hawkins S., Glaser A., Bedri S.K., Hillert J., Matute C., Antiguedad A.; ANZgene Consortium, Wiley J.S. (2015) “A rare P2X7 variant Arg307GIn with absent pore formation function protects against neuroinflammation in multiple sclerosis.” Hum Mol Genet. 2015 Oct 1;24(19):5644-54. doi: 10.1093/hmg/ddv278.Epub 2015 Jul 17. PubMed PMID: 26188005.

Field, J., Cortes, A., Glazov, E.A., Hadler, J., ANZGene Consortium, Stankovich, J., Brown, M.A. (2013) Resequencing and fine-mapping of the chromosome 12q13-14 locus associated with multiple sclerosis refines the number of implicated genes. Human Molecular Genetics. 22(11):2283-92

Ma, G.Z., Stankovich, J., Kilpatrick, T.K., Binder, M.D., Field, J. (2011). Polymorphisms in the Receptor Tyrosine Kinase MERTK Gene are Associated with Multiple Sclerosis Susceptibility. PLoS One 6(2): e16964.

Field, J., Browning, S.R., Johnson, L.J., Danoy, P., Varney, M.D., Tait, B.D., Gandhi, K.S., Charlesworth, J.C., Heard, R.N., Stewart, G.J., Kilpatrick, T.J., Foote, S.J., Bahlo, M., Butzkueven, H., Wiley, J., Booth, D.R., Taylor, B.V., Brown, M.A., Rubio, J.P., Stankovich, J. (2010). A polymorphism in the HLA-DPB1 gene is associated with susceptibility to multiple sclerosis. PLoS One  5(10): e13454

The Australian and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene). (2009) Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nat Genet 41:824-828

APHIA Proficiency testing program
Study ID: 2007/03

Field: Quality Assurance

Country: Australia

Recruitment: On going

Publications: None available

Analysis of Immune Reconstitution in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation
Study ID: 2009/02

Field: Not available

Country: USA

Recruitment: On going

Publications:

Blood, 15 October 2008, Vol 112 Number 8

Non-HLA genotyping study in a Western Australia multiple sclerosis cohort
Study ID: 2010/05

Field: Not available

Country: Australia

Recruitment: On going

Publications: None available

T-cell responses in drug hypersensitivity
Study ID: 2011/02

Field: Tissue samples, human genetics

Country: Australia

Recruitment: On going

Publications:

R Pavlos, E McKinnon, D Ostrov, B Peters, S Buus, D Koelle, A Chopra, C Rive, A Redwood, S Restrepo, A Bracey, J Yuan, S Gaudieri, M Carrington, D Haas, S Mallal, E Phillips. Peptide Binding Characteristics of HLA Alleles Associate with Cutaneous Nevirapine Hypersensitivuty. In submission, Nature Communications.

White KD, Chung WH, Hung SI, Mallal S, Phillips EJ. Evolving models of the immunopathogenesis of T cell-mediated drug allergy: The role of host, pathogens, and drug response. J Allergy Clin Immunol. 2015 Aug;136(2):219-34.

Metushi IG, Wriston A, Banerjee P, Gohlke BO, English AM, Lucas A, Moore C, Sidney J, Buus S, Ostrova DA, Mallal S, Phillips E, Shabanowitz J, Hunt DF, Preissner R, Peters B. Acyclovir Has Low but Detectable Influence on HLA-B*57:01 Specificity without Inducing Hypersensitivity. PLoS One. 2015 May 29;10(5):e0124878.

Lucas A, Lucas M, Strhyn A, Keane NM, McKinnon E, Pavlos R, Moran EM, Meyer-Pannwitt V, Gaudieri S, D’Orsogna L, Kalams S, Ostrov DA, Buus S, Peters B, Mallal S, Phillips E. Abacavir-reactive memory T cells are present in drug naive individuals. PLoS One. 2015 Feb 12;10(2):e0117160.

Milpied-Homsi B, Moran EM, Philips EJ. Antiviral drug allergy. Immunol Allergy Clin North Am. 2014 Aug;34(3):645-62.

Pavlos R, Mallal S, Ostrov D, Pompeu Y, Phillips E. Fever, rash, and systemic symptoms: understanding the role of virus and HLA in severe cutaneous drug allergy. J Clin Immunol Pract. 2014 Jan-Feb; 2(1):21-33.

White KD, Chung WH, Hung SI, Mallal S, Phillips EJ. Evolving models of the immunopathogenesis of T cell-mediated drug allergy: The role of host, pathogens, and drug response. J Allergy Clin Immunol. 2015 Aug;136(2):219-34.

Pavlos R, Mallal S, Ostrov D, Buus S, Metushi I, Peters B, Philips E. T cell-mediated hypersensitivity reactions to drugs. Anna Rev Med. 2015;66:439-54.

Pavlos R, Rive C, McKinnon E, Ostrov D, Plascencia P, Peters B, Yuan J, Gaudieri S, Haas D, Mallal S, Phillips E. Specific binding characteristics of HLA alleles associated with nevirapine hypersensitivity. [CROI abstract 804]. In Special Issue: Abstract from the 2014 Conference on Retroviruses and Opportunitistic Infections. Top Antivir Med 2014;22(e-1):417.
Rebecca Pavlos, Craig Rive, Elizabeth McKinnon, David Ostrov, Pablo C. Plascencia, Bjoern Peters, Jing Yuan, Silvana Gaudieri, David Haas, Soren Buus, Simon Mallal and Elizabeth Phillips. Mechanistic basis of Antiretroviral HLA-Associated drug hypersensitivities. Australian Centre for HIV and Hepatitis Virology Research, 10th Scientific Workshop, Lorne, Victoria, Australia. 6th June 2014. Abstract 45.

Keane NM, McKin Pavlos RK, non E, Lucas A, Rive C, Blyth CC, Dunn D, Lucas M, Mallal S, Phillips E. HLA Class I restricted CD8+ and Class II restricted CD4+ T cells are implicated in the pathogenesis of nevirapine hypersensitivity. AIDS. 2014 Aug 24;28(13):1891-901.

Elizabeth Phillips, John A. Bartlett, Ian Sanne, Michael M Lederman, John Hinkle, Franck Rousseau, David Dunn, Rebecca Pavlos, Ian James, Simon Mallal, David W. Haas. Associations between HLA-DRB1*0102, HLA-B*5801 and Hepatotoxicity during Initiation of Nevirapine-Containing Regimens in South Africa. J Acquir Immune Defic Syndr. 2013 Feb 1;62(2):e55-e57.

Ostrov D, Grant B, Pompeu Y, Sidney J, Harndahl M, Southwood S, Oseroff C, Lu S, Jakoncic J, de Oliveira C, Yang L, Mei H, Leming S, Shabanowitz J, English M, Wriston A, Lucas A, Phillips E, Mallal S, Grey H, Sett A, Hunt D, Buus S, Peters B. Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire. Proc Nat Acad Sci 2012; early edition Epub 29 May 2012; 109(25):9959-64.

Lucas A, Meyer-Pannvitt V, McKinnon E, Burrows S, Rist M, Leary S, Lucas M, Mallal S, Phillips E. Abacavir impairs an HLA-B*5701 restricted CD8+ T-cell response to an immunodominant Epstein-Barr virus (EBV) epitope. 20th Conference on Retroviruses and Opportunistic Infections 3-6 March 2013. Georgia, Atlanta, USA.

Mallal S, Phillips E. Abacavir and the altered peptide repertoire model: clinical implications. J In AIDS Soc 2012;15(6):18119. Oral presentation at HIV11, Glasgow, Scotland, November 13, 2012.

Lucas A, Lucas M, Pavlos R, Mallal S, Phillips E. Abacavir reactive HLA-B*57:01 restricted memory CD8+ T cells are present in abacavir unexposed donors. 19th Conference on Retroviruses and Opportunistic Infections, Seattle, Washington, USA, 5-9 March 2012, abstract 842.

HLA compatibility requirements for successful haematopoietic stem cell transplantation
Study ID: 2011/06

Field: Quality Assurance

Country: International – Multi centres

Recruitment: On going

Publications:

Petersdorf et al. and The International Histocompatibility Working Group in Hematopoietic Cell Transplantation (2013), 16th IHIW: International Histocompatibility Working Group in Hematopoietic Cell Transplantation. International Journal of Immunogenetics, 40: 2–10. doi: 10.1111/iji.12022

Tumour targeted T cells to enhance anti-tumour efficacy and dictate umbilical cord blood (UCB) engraftment in the setting of double UCB transplant
Study ID: 2012/02

Field: Qualitative methods – Human stem cells

Country: USA

Recruitment: On going

Publications: None available

Matched unrelated donor (MUD) factors predicting allogeneic haemopoietic stem cell yield in healthy donors
Study ID: 2012/03

Field: Quantitative research

Country: Australia

Recruitment: Closed

Publications: None available

In haemopoietic stem cell transplant patients, does infusion of infection-specific T-cells combined with vaccination (compared to no vaccination) enhance immune reconstitution safely?
Study ID: 2012/04

Field: Clinical trial

Country: Australia

Recruitment: On going

Publications: None available

The combination of common viral hits and heterologous immunity strongly influences clinical outcomes in “at risk” lungs
Study ID: 2012/05

Field: Tissue samples/ human stem cells

Country: Australia

Recruitment: On going

Publications:

Rowntree LC, Nguyen TH, Gras S, Kotsimbos TC, Mifsud NA. Deciphering the clinical relevance of allohuman leukocyte antigen cross-reactivity in mediating alloimmunity following transplantation. Curr Opin Organ Transplant. 2015 Nov 14.

The influence of genetics on the recovery of the immune system after stem cell transplant
Study ID: 2013/01

Field: Tissue samples/ human stem cells

Country: Australia

Recruitment: On going

Publications: None available

Does the donor immune genotype affect the outcome of matched unrelated donor stem cell transplant?
Study ID: 2013/02

Field: Tissue samples/ human stem cells

Country: Australia

Recruitment: On going

Publications: None available

Understanding how protein recognition by the immune system influence susceptibility to kidney disease
Study ID: 2013/03

Field: Tissue samples

Country: Australia

Recruitment: Closed

Publications:

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.

Ooi JD, Petersen J, Tan YH, Huynh M, Willett ZJ, Ramarathinam SH, Eggenhuizen PJ, Loh KL, Watson KA, Gan PY, Alikhan MA, Dudek NL, Handel A, Hudson BG, Fugger L, Power DA, Holt SG, Coates PT, Gregersen JW, Purcell AW, Holdsworth SR, La Gruta NL, Reid HH, Rossjohn J, Kitching AR.

Nature. 2017 May 3. doi: 10.1038/nature22329. [Epub ahead of print]

PMID: 28467828

What causes drug hypersensitivity?
Study ID: 2013/04

Field: Tissue samples

Country: Australia

Recruitment: On going

Publications: None available

CCR5 screening of donors
Study ID: 2014/04

Field: Quantitative methods/Human genetics

Country: Australia

Recruitment: On going

Publications: None available

Modelling the contribution of the indigenous cord blood program to increasing the donor pool for potential indigenous Australian recipients
Study ID: 2015/03

Field: Quantitative research

Country: Australia

Recruitment: Closed

Publications: None available

The role of dendritic cells in rheumatoid arthritis
Study ID: 2016/01

Field: Tissue samples

Country: Australia

Recruitment: On going

Publications: None available

A clinical trial of donor-derived WT1 specific T cells for prevention of relapse in combination with multiple pathogen specific T cells for prevention of infection in patients undergoing allogeneic haemopoietic stem cell transplant for acute myeloid leukaemia
Study ID: 2016/02

Field: Tissue samples

Country: Australia

Recruitment: On going

Publications: None available

ABMTRR Data Sharing Request
Study ID: 2017/01

Field: Quantitative research

Country: Australia

Recruitment: N/A

Publications: None available

Effect of freezing method on success of cord blood progenitor cell transplant
Study: 2017/02

Field: Quantitative research

Country: Australia

Recruitment: N/A

Publications: None available

Costing sub-study – paediatric matched unrelated transplants
Study: 2017/03

Field: Quantitative research

Country: Australia

Recruitment: N/A

Publications: None available