Current research

Finding genes that predispose to multiple sclerosis
Study ID: 2006/02Field: Not available

Country: Australia

Recruitment: On going

Publications:

Field J, Fox A, Jordan MA, Baxter AG, Spelman T, Gresle M, Butzkueven H, KILPATRICK T J, Rubio JP. lnterleukin-2 receptor-a proximal promoter hypomethylation is associated with multiple sclerosis. Genes and  Immunity (2017) 18 (2): 59-66.

Binder, M.D., Fox, A.D., Merlo, D., Johnson, L.J., Giuffrida, L., Calvert, S.E., Akkermann, R., Ma, G.Z.M., ANZgene, Perera, A.A., Gresle, M.M., Laverick, L., Foo, G. Fabis-Pedrini, M.J., Spelman, T., Jordan, M.A., Baxter, A.G., Foote, S., Butskueven, H., Kilpatrick, T.J., Field, J. (2016). “Common and low frequency variants in MERTK are independently associated with Multiple Sclerosis susceptibility with discordant association dependent upon HLA-DRB1*15:01 status” PLoS Genetics. 12(3):e1005853

Gu B.J., Field J., Dutertre S., Ou A., Kilpatrick T.J., Lechner-Scott J., Scott R., Lea R., Taylor B.V., Stankovich J., Butzkueven H., GresleM., Laws S.M., Petrou S., Hoffjan S., Akkad D.A., Graham C.A., Hawkins S., Glaser A., Bedri S.K., Hillert J., Matute C., Antiguedad A.; ANZgene Consortium, Wiley J.S. (2015) “A rare P2X7 variant Arg307GIn with absent pore formation function protects against neuroinflammation in multiple sclerosis.” Hum Mol Genet. 2015 Oct 1;24(19):5644-54. doi: 10.1093/hmg/ddv278.Epub 2015 Jul 17. PubMed PMID: 26188005.

Field, J., Cortes, A., Glazov, E.A., Hadler, J., ANZGene Consortium, Stankovich, J., Brown, M.A. (2013) Resequencing and fine-mapping of the chromosome 12q13-14 locus associated with multiple sclerosis refines the number of implicated genes. Human Molecular Genetics. 22(11):2283-92

Ma, G.Z., Stankovich, J., Kilpatrick, T.K., Binder, M.D., Field, J. (2011). Polymorphisms in the Receptor Tyrosine Kinase MERTK Gene are Associated with Multiple Sclerosis Susceptibility. PLoS One 6(2): e16964.

Field, J., Browning, S.R., Johnson, L.J., Danoy, P., Varney, M.D., Tait, B.D., Gandhi, K.S., Charlesworth, J.C., Heard, R.N., Stewart, G.J., Kilpatrick, T.J., Foote, S.J., Bahlo, M., Butzkueven, H., Wiley, J., Booth, D.R., Taylor, B.V., Brown, M.A., Rubio, J.P., Stankovich, J. (2010). A polymorphism in the HLA-DPB1 gene is associated with susceptibility to multiple sclerosis. PLoS One  5(10): e13454

The Australian and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene). (2009) Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nat Genet 41:824-828

APHIA Proficiency testing program
Study ID: 2007/03Field: Quality Assurance

Country: Australia

Recruitment: On going

Publications: None available

Analysis of Immune Reconstitution in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation
Study ID: 2009/02Field: Not available

Country: USA

Recruitment: On going

Publications:

Blood, 15 October 2008, Vol 112 Number 8

Non-HLA genotyping study in a Western Australia multiple sclerosis cohort
Study ID: 2010/05Field: Not available

Country: Australia

Recruitment: On going

Publications: None available

T-cell responses in drug hypersensitivity
Study ID: 2011/02Field: Tissue samples, human genetics

Country: Australia

Recruitment: On going

Publications:

Trubiano JA, Thursky KA, Stewardson AJ, Urbancic K, Worth LJ, Jackson C, Stevenson W, Sutherland M, Slavin MA, Grayson ML, Phillips EJ. 2017. Impact of an Integrated Antibiotic Allergy Testing Program on Antimicrobial Stewardship: A multicentre Evaluation. Clin. Infect. Dis. 65:166-174.

Trubiano JA, Strautins K, Redwood AJ, Pavlos R, Konvinse KC, Aung AK, Slavin MA, Thursky KA, Grayson ML, Phillips EJ. 2017. The Combined Utility of ex vivo IFN-γ Release Enzyme-Linked ImmunoSpot Assay and in vivo Skin Testing in Patients with Antibiotic-Associated Severe Cutaneous Adverse Reactions. J. Allergy. Clin. Immunol. Pract. doi:10.1016/j.jaip.2017.09.004.

Trubiano JA, Redwood A, Strautins K, Pavlos R, Woolnough E, Chang CC, Phillips E. 2017. Drug-specific upregulation of CD137 on CD8+ T cells aids in the diagnosis of multiple antibiotic toxic epidermal necrolysis. J. Allergy. Clin. Immunol. Pract. 5:823-826.

Thomas M, Hopkins C, Duffy E, Lee D, Loulergue P, Ripamonti D, Ostrov DA, Phillips E. 2017. Association of the HLA-B*53:01 Allele with Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome During Treatment of HIV Infection with Raltegravir. Clin. Infect. Dis. doi:10.1093/cid/cix096.

Somogyi AA, Phillips E. 2017. Genomic testing as a tool to optimise drug therapy. Australian Prescriber. 40:101-104.

Pavlos R, White KD, Wanjalla C, Mallal SA, Phillips EJ. 2017. Severe Delayed Drug Reactions: Role of Genetics and Viral Infections. Immunol. Allergy Clin. North Am. 37:785-815.

Pavlos R, Redwood A, Phillips E. 2017. AdDRESSing T-cell responses to antituberculous drugs. The Br. J. Derm. 176:292-293.

Pavlos R, McKinnon EJ, Ostrov DA, Peters B, Buus S, Koelle D, Chopra A, Schutte R, Rive C, Redwood A, Restrepo  S, Bracey A, Kaever T, Myers P, Speers E,  Malaker SA, Shabanowitz J, Jing Y, Gaudieri S, Hunt DF, Carrington M, Haas DW, Mallal S,  Phillips EJ. 2017. Shared peptide binding of HLA Class I and II alleles associate with cutaneous nevirapine hypersensitivity and identify novel risk alleles. Scientific Reports. 7:8653.

Garon SL, Pavlos RK, White KD, Brown NJ, Stone CA, Phillips EJ. 2017. Pharmacogenomics of off-target adverse drug reactions. Br. J. Clin. Pharmacol. 83:1896-1911.

Adler NR, Aung AK, Ergen EN, Trubiano J, Goh MSY, Phillips EJ. 2017. Recent advances in the understanding of severe cutaneous adverse reactions. Br. J. Clin. Pharmacol. 177:1234-1247.

Saito Y, Stamp LK, Caudle KE, Hershfield MS, McDonagh EM, Callaghan JT, Tassaneeyakul W, Mushiroda T, Kamatani N, Goldspiel BR, Phillips EJ, Klein TE, Lee MTM. 2016. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for human leukocyte antigen B (HLA-B) genotype and allopurinol dosing: 2015 update. Clin. Pharmacol. Ther. 99:36-37.

Phillips, EJ. 2016. Classifying ADRs – does dose matter? Rr. J. Clin. Pharmacol. 81:10-12.

Pavlos R, Strautins K, James I, Mallal S, Redwood AJ, Phillips E. 2016. Variation in EraP influences risk fr HLA-B*57:01 positive abacavir hypersensitivity, abstr 23rd Conference on Retroviruses and Opportunistic Infections (CROI), Boston, MA, 2016.

Konvinse K, White K, Pavlos R, Redwood A, Trubiano J, Ergen E, Mallal SA, Phillips EJ. 2016. Characterising immune responses in severe T-cell mediated adverse drug reaction. J. Immunol. 196:191.124-191.124.

Jing L, Laing KJ, Dong L, Russell RM, Barlow RS, Haas JG, Ramchandani MS, Johnston C, Buus S, Redwood AJ, White KD, Mallal SA, Phillips EJ, Posavad CM, Wald A, Koelle DM. 2016. Extensive CD4 and CD8 T Cell Cross-Reactivity between Alphaherpesviruses. J. Immunol. 196:2205-2218.

White KD, Chung WH, Hung SI, Mallal S, Phillips EJ. Evolving models of the immunopathogenesis of T cell-mediated drug allergy: The role of host, pathogens, and drug response. J Allergy Clin Immunol. 2015 Aug;136(2):219-34.

Metushi IG, Wriston A, Banerjee P, Gohlke BO, English AM, Lucas A, Moore C, Sidney J, Buus S, Ostrova DA, Mallal S, Phillips E, Shabanowitz J, Hunt DF, Preissner R, Peters B. Acyclovir Has Low but Detectable Influence on HLA-B*57:01 Specificity without Inducing Hypersensitivity. PLoS One. 2015 May 29;10(5):e0124878.

Lucas A, Lucas M, Strhyn A, Keane NM, McKinnon E, Pavlos R, Moran EM, Meyer-Pannwitt V, Gaudieri S, D’Orsogna L, Kalams S, Ostrov DA, Buus S, Peters B, Mallal S, Phillips E. Abacavir-reactive memory T cells are present in drug naive individuals. PLoS One. 2015 Feb 12;10(2):e0117160.

Milpied-Homsi B, Moran EM, Philips EJ. Antiviral drug allergy. Immunol Allergy Clin North Am. 2014 Aug;34(3):645-62.

Pavlos R, Mallal S, Ostrov D, Pompeu Y, Phillips E. Fever, rash, and systemic symptoms: understanding the role of virus and HLA in severe cutaneous drug allergy. J Clin Immunol Pract. 2014 Jan-Feb; 2(1):21-33.

Pavlos R, Mallal S, Ostrov D, Buus S, Metushi I, Peters B, Philips E. T cell-mediated hypersensitivity reactions to drugs. Anna Rev Med. 2015;66:439-54.

Pavlos R, Rive C, McKinnon E, Ostrov D, Plascencia P, Peters B, Yuan J, Gaudieri S, Haas D, Mallal S, Phillips E. Specific binding characteristics of HLA alleles associated with nevirapine hypersensitivity. [CROI abstract 804]. In Special Issue: Abstract from the 2014 Conference on Retroviruses and Opportunitistic Infections. Top Antivir Med 2014;22(e-1):417.

Rebecca Pavlos, Craig Rive, Elizabeth McKinnon, David Ostrov, Pablo C. Plascencia, Bjoern Peters, Jing Yuan, Silvana Gaudieri, David Haas, Soren Buus, Simon Mallal and Elizabeth Phillips. Mechanistic basis of Antiretroviral HLA-Associated drug hypersensitivities. Australian Centre for HIV and Hepatitis Virology Research, 10th Scientific Workshop, Lorne, Victoria, Australia. 6th June 2014. Abstract 45.

Keane NM, McKin Pavlos RK, non E, Lucas A, Rive C, Blyth CC, Dunn D, Lucas M, Mallal S, Phillips E. HLA Class I restricted CD8+ and Class II restricted CD4+ T cells are implicated in the pathogenesis of nevirapine hypersensitivity. AIDS. 2014 Aug 24;28(13):1891-901.

Elizabeth Phillips, John A. Bartlett, Ian Sanne, Michael M Lederman, John Hinkle, Franck Rousseau, David Dunn, Rebecca Pavlos, Ian James, Simon Mallal, David W. Haas. Associations between HLA-DRB1*0102, HLA-B*5801 and Hepatotoxicity during Initiation of Nevirapine-Containing Regimens in South Africa. J Acquir Immune Defic Syndr. 2013 Feb 1;62(2):e55-e57.

Ostrov D, Grant B, Pompeu Y, Sidney J, Harndahl M, Southwood S, Oseroff C, Lu S, Jakoncic J, de Oliveira C, Yang L, Mei H, Leming S, Shabanowitz J, English M, Wriston A, Lucas A, Phillips E, Mallal S, Grey H, Sett A, Hunt D, Buus S, Peters B. Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire. Proc Nat Acad Sci 2012; early edition Epub 29 May 2012; 109(25):9959-64.

Lucas A, Meyer-Pannvitt V, McKinnon E, Burrows S, Rist M, Leary S, Lucas M, Mallal S, Phillips E. Abacavir impairs an HLA-B*5701 restricted CD8+ T-cell response to an immunodominant Epstein-Barr virus (EBV) epitope. 20th Conference on Retroviruses and Opportunistic Infections 3-6 March 2013. Georgia, Atlanta, USA.

Mallal S, Phillips E. Abacavir and the altered peptide repertoire model: clinical implications. J In AIDS Soc 2012;15(6):18119. Oral presentation at HIV11, Glasgow, Scotland, November 13, 2012.

Lucas A, Lucas M, Pavlos R, Mallal S, Phillips E. Abacavir reactive HLA-B*57:01 restricted memory CD8+ T cells are present in abacavir unexposed donors. 19th Conference on Retroviruses and Opportunistic Infections, Seattle, Washington, USA, 5-9 March 2012, abstract 842.

HLA compatibility requirements for successful haematopoietic stem cell transplantation
Study ID: 2011/06Field: Quality Assurance

Country: International – Multi centres

Recruitment: On going

Publications:

Petersdorf et al. and The International Histocompatibility Working Group in Hematopoietic Cell Transplantation (2013), 16th IHIW: International Histocompatibility Working Group in Hematopoietic Cell Transplantation. International Journal of Immunogenetics, 40: 2–10. doi: 10.1111/iji.12022

The influence of genetics on the recovery of the immune system after stem cell transplant
Study ID: 2013/01Field: Tissue samples/ human stem cells

Country: Australia

Recruitment: On going

Publications: None available

Does the donor immune genotype affect the outcome of matched unrelated donor stem cell transplant?
Study ID: 2013/02Field: Tissue samples/ human stem cells

Country: Australia

Recruitment: On going

Publications: None available

CCR5 screening of donors
Study ID: 2014/04Field: Quantitative methods/Human genetics

Country: Australia

Recruitment: On going

Publications:

Koelsh, Kersten K. MD et al Impact of Allogenic Hematopoietic Stem Cell Transplantation on the HIV Reservoir and Immune response in 3 HIV-Infected Individuals. JAIDS Journal of Acquired Immune Deficiency Syndromes: I July 2017 – Volume 75.

The role of dendritic cells in rheumatoid arthritis
Study ID: 2016/01Field: Tissue samples

Country: Australia

Recruitment: On going

Publications: None available

A clinical trial of donor-derived WT1 specific T cells for prevention of relapse in combination with multiple pathogen specific T cells for prevention of infection in patients undergoing allogeneic haemopoietic stem cell transplant for acute myeloid leukaemia
Study ID: 2016/02Field: Tissue samples

Country: Australia

Recruitment: On going

Publications: None available

Study of adverse reactions to therapeutic drugs
Study ID: 2016/04Field: Tissue samples

Country: Australia

Recruitment: Closed

Publications: None available

ABMTRR Data Sharing Request
Study ID: 2017/01Field: Quantitative research

Country: Australia

Recruitment: N/A

Publications: None available

Effect of freezing method on success of cord blood progenitor cell transplant
Study: 2017/02Field: Quantitative research

Country: Australia

Recruitment: N/A

Publications: None available

The establishment of a repository of in vitro expanded T cells for the treatment of viral complications in transplant recipients
Study: 2017/05Field: Tissue samples

Country: Australia

Recruitment: On going

Publications: None available

Using donor blood to manufacture highly effective T-cells to fight viral infections post-transplant
Study: 2017/06Field: Tissue samples

Country: USA

Recruitment: On going

Publications:

Nelson AS, Heyenbruch D, Darnen A, Gong N, Maurer K, Zhu X, Wilhelm J, Fohl D, Sper C, Bonavita A, Davies SM, Lutzko C, Bollard CM, Hanley PJ, Leemhuis T, Grimley M. Building a third-party VST bank from scratch- the Cincinnati experience. BBMT March 2018; 24(3): S90

Heyenbruch D, Darnen A, Gong N, Maurer K, Grimley M, Nelson AS, Davies SM, Lutzko C, Leemhuis T. Production of trivalent antigen-specific T cells utilizing viral peptide stimulation. BBMT 2018; 24(3): S 172-173

Protective HLA-DR alleles in anti-glomerular basement membrane disease
Study: 2018/04Field: Tissue samples

Country: Australia

Recruitment: On going

Publications: None available